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“Orientational isomerism” is a concept necessary for deeper understanding of the selective reactivities in a host-guest system. This concept has been rarely explored in the context of supramolecular host guest chemistry. We designed a model system including four cyclohexene derivatives and a water-soluble host Octa Acid (OA), with hydrophobic inner cavity. The overall length of the guest molecules (~ 12 Å) was limited by manipulating the alkyl substituents at 1- and 4-positions on the cyclohexene ring. 1D 1H /2D COSY and NOESY NMR and photooxygenation reaction were used to understand the observations with this model system. Specific packaging or “orientational isomerism” of each guest molecule, induced by the host OA led to specific, in one case enhanced product selectivity. With this model system we show the important role of “orientational isomerism” in explaining enhanced product selectivity in a host-guest supramolecular system. 

We study the band structure and scattering of in-plane coupled longitudinal and shear stress waves in linear layered media and observe that exceptional points (EP) appear for elastic (lossless) media, when parameterized with real-valued frequency and tangential wave vector component. The occurrence of these EP pairs is not limited to the original stop bands. They could also appear in all mode pass bands, leading to the formation of new stop bands. The scattered energy near these locations is studied along with the associated polarization patterns. The broken phase symmetry is observed inside the frequency bands book-ended by these EP pairs. This is especially manifested by the chirality of the trajectory of the particle velocity, which gets selected by a ‘‘direction’’ of the wave, e.g. the imaginary part of normal component of the wave vector, or the energy flux direction just outside the band. Additionally, EP pairs also appear in the spectrum of the (modified) scattering matrix when mechanical gain is theoretically included to balance the loss in a parity-time symmetric finite structure. These EP pairs lead to amplification of transmission to above 1 and single-sided reflectivity, both phenomena associated with broken phase symmetry, with intriguing potential applications. 

This paper draws on Michel de Certeau’s notion of "tactics" to explore the use of data in labor organizing research in CSCW [? ]. Taking a historical view, we first analyze a set of cases from 20th century US labor history that offer three distinct lenses on the risks of data-based advocacy campaigns: wagers, compromises, and concessions. Across our cases, we frame reformers’ use of data tactics as a rhetorical move, taken to advance incremental worker gains under conditions of precarity [90, 105, 154]. However, by continuing to rely on certain data-based arguments in the short term, we argue that labor reformers may have limited the frame of debate for broader arguments necessary to improve conditions in the long-term. These tensions follow us into data-based advocacy research in the present, such as the emerging "digital workerism" movement [70]. To ensure the continuation of responsible advocacy research in CSCW, we offer insights from social justice movements to suggest how members of the HCI and CSCW communities can work more intentionally alongside (or without) data methods to support worker-led direct action. 

Operators of web archives have two options for how to crawl pages from the web. Browser-based dynamic crawlers capture all of the resources on every page, but incur high compute overheads. Static browserless crawlers are more lightweight, but miss page resources which are fetched only when scripts are executed. In this paper, we make the case that a web archive does not have to make a binary choice between dynamic or static crawling. Instead, by using a browser for a carefully chosen small subset of crawls, an archive can significantly improve its ability to serve statically crawled pages with high fidelity. First, we show how to reuse crawled resources, both across pages and across multiple crawls of the same page over time. Second, by leveraging a dynamic crawl of a page, we show that subsequent static crawls of the page can be augmented to fetch resources without executing the scripts which request them. We estimate that, as long as 8.9% of page crawls use a browser, an archive can serve roughly 99% of the remaining statically crawled pages without any loss in fidelity, up from 55% without our techniques. 

The Sun is the most studied of all stars, and thus constitutes a benchmark for stellar models. However, our vision of the Sun is still incomplete, as illustrated by the current debate on its chemical composition. The problem reaches far beyond chemical abundances and is intimately linked to microscopic and macroscopic physical ingredients of solar models such as radiative opacity, for which experimental results have been recently measured that still await the- oretical explanations. We present opacity profiles derived from helioseismic inferences and compare them with detailed theoretical computations of individual element contributions using three different opacity computation codes, in a complementary way to experimental results. We find that our seismic opacity is about 10% higher than theoretical values used in current solar models around 2 million degrees, but lower by 35% than some recent available theoretical values. Using the Sun as a laboratory of fundamental physics, we show that quantitative comparisons between various opacity tables are required to understand the origin of the discrepancies between reported helioseismic, theoretical and experimental opacity values. 

Neurons throughout the neocortex exhibit selective sensitivity to particular features of sensory input patterns. According to the prevailing views, cortical strategy is to choose features that exhibit predictable relationship to their spatial and/or temporal context. Such contextually predictable features likely make explicit the causal factors operating in the environment and thus they are likely to have perceptual/behavioral utility. The known details of functional architecture of cortical columns suggest that cortical extraction of such features is a modular nonlinear operation, in which the input layer, layer 4, performs initial nonlinear input transform generating proto-features, followed by their linear integration into output features by the basal dendrites of pyramidal cells in the upper layers. Tuning of pyramidal cells to contextually predictable features is guided by the contextual inputs their apical dendrites receive from other cortical columns via long-range horizontal or feedback connections. Our implementation of this strategy in a model of prototypical V1 cortical column, trained on natural images, reveals the presence of a limited number of contextually predictable orthogonal basis features in the image patterns appearing in the column’s receptive field. Upper-layer cells generate an overcomplete Hadamard-like representation of these basis features: i.e., each cell carries information about all basis features, but with each basis feature contributing either positively or negatively in the pattern unique to that cell. In tuning selectively to contextually predictable features, upper layers perform selective filtering of the information they receive from layer 4, emphasizing information about orderly aspects of the sensed environment and downplaying local, likely to be insignificant or distracting, information. Altogether, the upper-layer output preserves fine discrimination capabilities while acquiring novel higher-order categorization abilities to cluster together input patterns that are different but, in some way, environmentally related. We find that to be fully effective, our feature tuning operation requires collective participation of cells across 7 minicolumns, together making up a functionally defined 150 μm diameter “mesocolumn.” Similarly to real V1 cortex, 80% of model upper-layer cells acquire complex-cell receptive field properties while 20% acquire simple-cell properties. Overall, the design of the model and its emergent properties are fully consistent with the known properties of cortical organization. Thus, in conclusion, our feature-extracting circuit might capture the core operation performed by cortical columns in their feedforward extraction of perceptually and behaviorally significant information. 

Abstract Electric field-induced splay of molecular orientation, called the Fréedericksz transition, is a fundamental electro-optic phenomenon in nonpolar nematic liquid crystals. In a ferroelectric nematic N_Fwith a spontaneous electric polarization$${{\bf{P}}}$$ $P$, the splay is suppressed since it produces bound electric charges. Here, we demonstrate that an alternating current (ac) electric field causes three patterns of N_Fpolarization. At low voltages,$${{\bf{P}}}$$ $P$oscillates around the field-free orientation with no stationary deformations. As the voltage increases, the polarization acquires stationary distortions, first splay and twist in a stripe pattern and then splay and bend in a square lattice of +1 and -1 defects. In all patterns,$${{\bf{P}}}$$ $P$oscillates around the stationary orientations. The stationary bound charge is reduced by a geometrical “splay cancellation” mechanism that does not require free ions: the charge created by splay in one plane is reduced by splay of an opposite sign in the orthogonal plane. 

Abstract Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (AR) clears neurofibrillary tangles (NFTs) and rescues neuronal tauopathy-associated defects. AR reduced levels of phospho-tau and lowered NFT burden by a mechanism involving the energy-sensing kinase AMPK and the growth-sensing kinase GSK3b. The transcriptional response to AR included broad metabolic and functional pathways. Induction of lysosomal pathways involved activation of LC3 and p62, and restoration of neuronal outgrowth required the stress-responsive kinase JNK. Negative consequences of NFTs on mitochondrial activity, ATP production, and lipid stores were corrected. Defects in electrophysiological measures (e.g., resting potential, resistance, spiking profiles) were also corrected. These findings reveal a network linking mitochondrial function, cellular maintenance processes, and electrical aspects of neuronal function that can be targeted via adiponectin receptor activation.